Tim Fernholz is a journalist who writes about technology, finance and public policy. He has closely covered the rise of the private space industry and is the author of Rocket Billionaires: Elon Musk, Jeff Bezos and the New Space Race. Formerly, he was a senior reporter at Quartz, the global business news site, for more than a decade, and began his career as a political reporter in Washington, D.C.
“How am I even supposed to answer that question?”
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Whether or not we’re going to go to war in a foreign country, in the Trump administration, has now become the sort of thing that some people know, and most people don’t know, and we are betting on. And then right inside of that is, well, some people know, and now they have an enormous incentive to bet on it as well. And so you see insider trading happening all over these prediction markets, and I, for the life of me, cannot tell if that is a bug or a feature.
From here, the actual sequencing can begin. Primers and fluorescently-labeled chain terminators are added to the reaction mixture, resulting in the addition of one nucleotide to each strand of DNA on the lawn. A picture is taken of the entire chip, then the chain terminators’ blockers are cleaved to allow addition of the next base. This process proceeds until the reaction is complete, resulting in massively parallelized sequencing. The short reads acquired through this process can be combined via a computational technique called paired end analysis, which links reads by analyzing overlapping sections, to generate the whole sequence.
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